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FAQs

Osteoarthritis (OA)

Patients- What is osteoarthritis (OA)?

Osteoarthritis (OA) is the most common type of arthritis and can cause joints to feel stiff and painful. It is more common in older people but can also affect younger people especially if there has been an injury to a joint. Sometimes OA causes the joints to swell and change shape and sometimes the joints make creaking or cracking noises.

The symptoms of osteoarthritis can vary a lot. Sometimes there is no pain at all and sometimes the pain can be severe and moving them is difficult. There can be loss of muscle around the joints and this can make them feel weaker. Almost all joints can develop osteoarthritis but the most common places are the fingers, thumbs, knees and hips as well as the low back and neck.

Patients- What is the place for Arthrosamid® in the managing of knee osteoarthritis?

If the patient suffers with osteoarthritis pain and the pain is not controlled by simple pain killers and lifestyle modifications, then the patient could be suitable for Arthrosamid®treatment.

Patients - Can I receive Arthrosamid® treatment in both my knees?

Yes, it is possible to have both knees injected but your physician is best placed to decide the time period before the treatments.

Patients- Can I receive Arthrosamid® treatment for hip osteoarthritis?

No - Arthrosamid® is only indicated for the knee osteoarthritis symptomatic treatment.

Patients- What other joints can the gel be used in?

Studies with Arthrosamid® have only been carried out for the treatment of Knee osteoarthritis so at this time it is only indicated for use in the knee.

What is it?

Patients- What is polyacrylamide hydrogel?

A polyacrylamide hydrogel is a group of cross-linked polymeric material, which hold large amounts of water while maintaining their structure. They possess a degree of flexibility very similar to natural tissue due to their large water content.
Arthrosamid® is a hydrogel. It is an inert, non-pyrogenic polymer gel consisting of 97.5% sterile water and 2.5% cross-linked polyacrylamide and has water exchanging capabilities.

Patients - What is Arthrosamid®?

Arthrosamid®, intra-articular polyacrylamide hydrogel injection (iPAAG), is a non-biodegradable single-dose injection that delivers long-acting symptomatic treatment to adult patients with knee osteoarthritis.

Patients - How is Arthrosamid® different than other injections ?

Arthrosamid® is different from viscosupplement injections such as Hyaluronic Acid (HA), Platelet Rich Plasma (PRP) and regenerative stem cell therapy. Unlike these treatments, Arthrosamid® becomes an integrated part of the soft synovial tissue in the joint capsule and provides long-acting and sustain pain relief.

Is it Safe?

Patients- Is the treatment painful?

Before you are given an Arthrosamid® injection, you will also have a local anaesthetic to numb the area around your knee. The most common adverse events (side effects) in clinical trials were Injection-related mild to moderate pain and or mild swelling during the first weeks to months after the injection.

Patients - Why are prophylactic antibiotics recommended?

Arthrosamid® must be administered with prophylactic antibiotics due to the permanent nature of the scaffold implant. A high concentration on antibiotics in the tissue at the time of injection (should be given only once) may reduce infection risk. Details can be found in the product IFU (Instructions For Use).

Does it work?

Patients - Can Arthrosamid® delay joint replacement surgery?

Viscosupplementation has been shown to delay time to total knee joint replacement. The long lasting and sustained effect of Arthrosamid® should offer similar benefits.

Patients - Can I get another treatment if the 1st treatment effect wears off? After what period of time?

The treatment could be repeated if required and advised by your doctor. It is not recommended to repeat the treatment within 6 months.

What is the treatment like?

Patients- Is the treatment painful?

Before you are given an Arthrosamid® injection, you will also have a local anaesthetic to numb the area around your knee. The most common adverse events (side effects) in clinical trials were Injection-related mild to moderate pain and or mild swelling during the first weeks to months after the injection.

Patients - How is Arthrosamid® different than other injections ?

Arthrosamid® is different from viscosupplement injections such as Hyaluronic Acid (HA), Platelet Rich Plasma (PRP) and regenerative stem cell therapy. Unlike these treatments, Arthrosamid® becomes an integrated part of the soft synovial tissue in the joint capsule and provides long-acting and sustain pain relief.